Evaluation of Cytokeratin 19 Fragment (CYFRA 21-1) as a Tumor Marker in Malignant Pleural Effusion
نویسندگان
چکیده
منابع مشابه
Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma.
BACKGROUND The clinical utility of tumour markers in pleural effusion is still controversial with regard to the efficient detection of malignant pleural mesothelioma (MPM). PATIENTS AND METHODS The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) were retrospectively studied in pleural effusion of unknown origin in patients who had undergone medical thoracosco...
متن کاملSerum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer.
Cytokeratin 19 is a subunit of cytokeratin intermediate filament expressed in simple epithelia and their malignant counterparts. Therefore, it is expressed by respiratory epithelium cells and has been detected in lung cancer specimens. An immunoradiometric assay was used to detect a fragment of the cytokeratin 19, referred to as CYFRA 21-1, in the serum of 165 patients with histologically prove...
متن کاملCYFRA 21-1, a cytokeratin subunit 19 fragment, in bronchoalveolar lavage fluid from patients with interstitial lung disease.
1. It has been suggested that CYFRA21-1, a cytokeratin subunit 19 fragment, is potentially useful for diagnosis and monitoring of lung carcinoma. However, serum levels of CYFRA21-1 are also increased in a high proportion of patients with interstitial lung disease. In this study we measured CYFRA21-1 levels in bronchoalveolar lavage fluid from 10 normal subjects, 18 patients with idiopathic pulm...
متن کاملThe diagnostic value of parallel detection of cytokeratin 19 fragment-based tumor markers in malignant pleural effusion: a systematic review and meta-analysis
Background: Cytokeratin 19 Fragment (CYFRA 21-1) is one of the commonly used tumor markers in clinical practice. The examination of CYFRA 21-1 in pleural effusions may help establish the diagnosis of Malignant Pleural Effusion (MPE). However, given the relatively low sensitivity, it is often used in combination with other tumor markers. Thus, we performed this systematic review and meta-analysi...
متن کاملCYFRA 21-1 as a tumour marker for bronchogenic carcinoma.
Despite extensive research, the role of the commonly employed tumour markers in the diagnosis of lung carcinoma is yet to be clarified. The utility of a new marker, CYFRA 21-1, in the preoperative evaluation of patients with bronchogenic carcinoma was investigated. CYFRA 21-1 was determined with a radiometric assay in serum of 280 patients with lung cancer and 208 patients with various nonmalig...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 1999
ISSN: 0368-2811,1465-3621
DOI: 10.1093/jjco/29.9.421